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Permeation of Organometallic Compounds through Phospholipid Membranes

von Dr. Raycho Yonchev

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[1.] Ry/Fragment 013 01 - Diskussion
Zuletzt bearbeitet: 2016-04-10 12:53:24 WiseWoman
Anézo 2003, Fragment, Gesichtet, KomplettPlagiat, Ry, SMWFragment, Schutzlevel sysop

Typus
KomplettPlagiat
Bearbeiter
Klgn
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Untersuchte Arbeit:
Seite: 13, Zeilen: 1 ff. (entire page)
Quelle: Anézo 2003
Seite(n): 27, 28, Zeilen: 27:18f; 28:1ff
The main disadvantages of monolayers as membrane models are twofold – some of the monolayer properties might differ from those of a bilayers; a second difficulty resides in the choice of the lateral surface pressure to apply to mimic the properties of a real membrane.

Membrane computer models have a short history compared to experimental models. In the last decade, computer simulations such as Monte Carlo or molecular dynamics (MD) simulations emerged as a powerful tool to gain detailed insights into the molecular structure and dynamics of biomembranes. Various lipid bilayers systems have been simulated, incorporating or not membrane proteins. The two major limitations of such membrane simulations involve the system size and the accessible time scale. However, computer simulations constitute an irreplaceable technique to probe membrane properties at the atomic level. Strong and weak points of the MD approach will be discussed in the next chapter.

Each of the membrane model systems described above presents advantages and disadvantages, the one providing insight into membrane regions to which the other does not have access. Information from each kind of systems turns out to be very useful for the better understanding of specific membrane properties and can be combined to refine the fluid mosaic model.

I.2. Phospholipid properties relevant to biomembranes

In spite of their complexity and their specific differences in composition, all biomembarnes [sic] have the same universal structure – the basic structural element is provided by a lipid bilayers. Among membrane lipids, phospholipids constitute an important class with regard to their occurrence in cell membranes and their ability to form bilayers vesicles spontaneously when dispersed in water. The understanding of their physical and chemical behavior is essential in order to appreciate many of the properties of biological membranes.

[page 27]

The main disadvantages of monolayers as membrane models are twofold: some of the monolayer properties might differ from those of a bilayer; a second difficulty resides in the choice of the lateral surface pressure to apply to mimic the properties of a real membrane.

Membrane computer models Membrane computer models have a short history compared to experimental models. In the last decade, computer simulations such as Monte Carlo (MC) or molecular dynamics (MD) simulations emerged as a powerful tool to gain detailed insights into the molecular structure and dynamics of biomembranes. Various lipid bilayer systems have been simulated, incorporating or not membrane proteins. The two major limitations of such membrane simulations involve the system size and the accessible time scale. However, computer simulations constitute an irreplaceable technique to probe membrane properties at the atomic level. Strong and weak points of the MD approach will be extensively discussed in the next chapters.

[page 28]

Each of the membrane model systems described above presents advantages and disadvantages, the one providing insight into membrane regions to which the other does not have access. Information from each kind of systems turns out to be very useful for the better understanding of specific membrane properties and can be combined to refine the fluid mosaic model.

1.2 Phospholipid properties relevant to biomembranes

In spite of their complexity and their specific differences in composition, all biomembranes have the same universal structure: the basic structural element is provided by a lipid bilayer. Among membrane lipids, phospholipids constitute an important class (see Section 1.1.2.1, page 13) with regard to their occurrence in cell membranes and their ability to form bilayer vesicles spontaneously when dispersed in water. The understanding of their physical and chemical behavior is essential in order to appreciate many of the properties of biological membranes.

Anmerkungen

No source is given.

Sichter
(Klgn), WiseWoman


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