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[1.] Shg/Fragment 012 21 - Diskussion Zuletzt bearbeitet: 2014-11-03 14:52:25 Hindemith | Foradori et al 2008, Fragment, Gesichtet, SMWFragment, Schutzlevel sysop, Shg, Verschleierung |
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The classic genomic model for steroid hormone action presumes that steroid hormones can freely cross the Plasma Membrane, enter the cytoplasm, and bind to activate specific iAR. The bound steroid receptors act as transcription factors and bind as homodimers or heterodimers to specific DNA response elements in target gene promoters, causing protein synthesis. [Guido M, Uta C.P. 2008]
Guido M, Uta C.P. (2008). Raptid action of androgens. Neuroendocrinology 29: 182-198. |
This classic genomic model for steroid hormone action presumes that steroid hormones can freely cross the plasma membrane, enter the cytoplasm, and bind to and activate specific intracellular steroid receptor proteins. The bound steroid receptors act as transcription factors and bind as homodimers or heterodimers to specific DNA response elements in target gene promoters, causing activation or repression of transcription and subsequently protein synthesis (Figure 1) [2; 3; 4; 5; 6].
2. Beato M. Gene regulation by steroid hormones. Cell. 1989;56:335–344. [PubMed] 3. Roy AK, Lavrovsky Y, Song CS, Chen S, Jung MH, Velu NK, Bi BY, Chatterjee B. Regulation of androgen action. Vitam Horm. 1999;55:309–352. [PubMed] 4. Heinlein CA, Chang C. Androgen receptor (AR) coregulators: an overview. Endocr Rev. 2002;23:175–200. [PubMed] 5. Zhou ZX, Wong CI, Sar M, Wilson EM. The androgen receptor: an overview. Recent Prog Horm Res. 1994;49:249–274. [PubMed] 6. Quigley CA, De Bellis A, Marschke KB, el-Awady MK, Wilson EM, French FS. Androgen receptor defects: historical, clinical, and molecular perspectives. Endocr Rev. 1995;16:271–321. [PubMed] |
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