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Typus
Verschleierung
Bearbeiter
SleepyHollow02, Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 25, Zeilen: 1-9
Quelle: Gewies 2003
Seite(n): 4, Zeilen: 18-27
[Those morphological changes are consequences of] characteristic molecular and biochemical events which occur in an apoptotic cell. Most of them are activated notably by proteolytic enzymes. It finally mediates the cleavage of DNA into oligonucleosomal fragments, in at the same time as the cleavage of a multitude of specific protein substrates which usually determine the integrity and shape of the cytoplasm or organelles [Saraste, A; Pulkki, K 2000]. Furthermore, apoptosis is in contrast to the necrotic mode of cell-death. During necrosis, the cellular contents are released uncontrolled into the cell's environment, which results in damage of surrounding cells and a strong inflammatory response in the corresponding tissue.

Saraste, A and Pulkki, K (2000). "Morphologic and biochemical hallmarks of apoptosis." Cardiovasc Res 45(3): 528-37.

Those morphological changes are a consequence of characteristic molecular and biochemical events occurring in an apoptotic cell, most notably the activation of proteolytic enzymes which eventually mediate the cleavage of DNA into oligonucleosomal fragments as well as the cleavage of a multitude of specific protein substrates which usually determine the integrity and shape of the cytoplasm or organelles [Saraste, 2000]. Apoptosis is in contrast to the necrotic mode of cell-death in which case the cells suffer a major insult, resulting in a loss of membrane integrity, swelling and disrupture of the cells. During necrosis, the cellular contents are released uncontrolled into the cell's environment which results in damage of surrounding cells and a strong inflammatory response in the corresponding tissue [Leist, 2001a].

Saraste, A and Pulkki, K (2000). "Morphologic and biochemical hallmarks of apoptosis." Cardiovasc Res 45(3): 528-37.

Leist, M and Jaattela, M (2001). "Four deaths and a funeral: from caspases to alternative mechanisms." Nat. Rev. Mol. Cell Biol. 2(8): 589-98.

Anmerkungen

Ohne Hinweis auf eine Übernahme.

Sichter
(SleepyHollow02), (Graf Isolan), Hindemith

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