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Typus
Verschleierung
Bearbeiter
SleepyHollow02
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Untersuchte Arbeit:
Seite: 82, Zeilen: 1-10, 22-25
Quelle: Gu et al 2009
Seite(n): 0, Zeilen: 0
6. Conclusions

In conclusion, the results presented here add a clear and significant piece of evidence on the potential anti-tumorigenic role of membrane androgen receptors.

They indicate that

  • The functional mAR is expressed not only in hormone-dependent tumors but also in colon tumors.
  • mAR conjugates also induced rapid actin and tubulin reorganization.
  • The activation through steroid albumin conjugates induces potent pro-apoptotic responses regulated by cytoskeletal rearrangements.

[...]

These receptors may represent specific targets for the development of novel drugs since their activation drastically regress tumor growth and tumor incidence in vivo

In conclusion, the results presented here add a clear and significant piece of evidence to the potential anti-tumorigenic role of membrane androgen receptors. They indicate that a) functional mAR are expressed not only in hormone- dependent tumors but also in colon tumors, b) their activation through steroid albumin conjugates induces potent pro-apoptotic responses regulated by cytoskeletal rearrangements, and c) these receptors may represent specific targets for the development of novel Molecular Cancer 2009, 8:114 http://www.molecular-cancer.com/content/8/1/114 Page 13 of 14 (page number not for citation purposes) drugs, since their activation drastically regresses tumor growth and tumor incidence in vivo. Additional experiments are now required for the identification of the molecular identity of these receptors.
Anmerkungen

Substantial parts of the Conclusion seem to have been published two years before the thesis.

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