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Typus
KomplettPlagiat
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 7, Zeilen: 1-19
Quelle: Uldry and Thorens 2004
Seite(n): 480, Zeilen: r.col: 9ff
[Signature sequences conserved between the] different members of the SLC2 family are present at distinct locations in the primary structure. The presence of these sequences, however, does not predict the substrate specificity of these transporters.

Glucose transporters are expressed in every cell of the body, as might be anticipated from the key role of glucose in providing metabolic energy and building blocks for the synthesis of biomolecules. The specific physiological role of the isoforms expressed in tissues involved in the control of glucose homeostasis, i.e. muscle, adipose tissue, liver, pancreatic beta-cells and brain, has been studied in greatest detail. Indeed, in these tissues glucose transporters play important roles in the control of glucose utilization, glucose production and glucose sensing and their dysregulated expression may underlie pathogenetic mechanisms leading to development of diabetes mellitus, but also other specific monogenic diseases (17).

Facilitated diffusion of glucose across plasma membranes has been studied for several decades (18). The recognition that human erythrocytes have a high density of glucose transporters allowed the initial biochemical purification of this transporter and the preparation of specific antibodies. These were then used for initial cloning of a human glucose transporter by screening an expression library prepared from a human hepatoma cell line (HepG2) (4).This glucose transporter, named GLUT1 (SLC2A1) , was then used for subsequent cloning, by low-stringency screening, of GLUT2–5 (SLC2A2, SLC2A3, SLC2A4, SLC2A5)


4. Kloppel,G, Lohr,M, Habich,K, Oberholzer,M, Heitz,PU: Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited. Surv.Synth.Pathol.Res. 4:110-125, 1985

17. Fernandez,EB: [Monogenic forms of diabetes mellitus]. An.R.Acad.Nac.Med.(Madr.) 123:211-217, 2006

18. Gylfe,E, Grapengiesser,E, Hellman,B: Propagation of cytoplasmic Ca2+ oscillations in clusters of pancreatic beta-cells exposed to glucose. Cell Calcium 12:229-240, 1991

Signature sequences conserved between the different members of the SLC2 family are present at distinct locations in the primary structure (Fig. 2). The presence of these sequences, however, does not predict the substrate specificity of these transporters.

Glucose transporters are expressed in every cell of the body, as might be anticipated from the key role of glucose in providing metabolic energy and building blocks for the synthesis of biomolecules. The specific physiological role of the isoforms expressed in tissues involved in the control of glucose homeostasis, i.e. muscle, adipose tissue, liver, pancreatic beta- cells and brain, has been studied in greatest detail. Indeed, in these tissues glucose transporters play important roles in the control of glucose utilization, glucose production and glucose sensing and their dysregulated expression may underlie pathogenetic mechanisms leading to development of diabetes mellitus, but also other specific monogenic diseases (see below).

Facilitated diffusion of glucose across plasma membranes has been studied for several decades [43]. The recognition that human erythrocytes have a high density of glucose transporters allowed the initial biochemical purification of this transporter and the preparation of specific antibodies. These were then used for initial cloning of a human glucose transporter by screening an expression library prepared from a human hepatoma cell line (HepG2) [53]. This glucose transporter, GLUT1, was then used for subsequent cloning, by low-stringency screening, of GLUT2–5.


43. Lieb WR, Stein WD (1971) New theory for glucose transport across membranes. Nat New Biol 230:108–109

53. Mueckler M, Caruso C, Baldwin SA, Panico M, Blench I, Morris HR, Allard WJ, Lienhard GE, Lodish HF (1985) Sequence and structure of a human glucose transporter. Science 229:941–945

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