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Typus
Verschleierung
Bearbeiter
Hindemith
Gesichtet
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Untersuchte Arbeit:
Seite: 12, Zeilen: 3-7
Quelle: Bryant et al 2002
Seite(n): 267, Zeilen: r.col: 13ff
Earlier it was found that, in rat adipocytes insulin triggers the movement of the sugar transporter that is found in these cells from cytoplam to the plasma membrane. That was later confirmed when GLUT4 was identified as the main glucose transporter in these cells. GLUT4 primarily found in muscle and fat cells, is found in a complex intracellular tubulo–vesicular network that is connected to the endosomal–trans-Golgi network (TGN) system. In 1980, it was reported that, in rat adipocytes, insulin triggers the movement of the sugar transporter that is found in these cells from an intracellular store to the plasma membrane2,3.This translocation hypothesis was later confirmed when GLUT4 was identified as the main glucose transporter in these cells. GLUT4, which is expressed primarily in muscle and fat cells, is found in a complex intracellular tubulo–vesicular network that is connected to the endosomal–trans-Golgi network (TGN) system.

2. Suzuki, K. & Kono, T. Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site. Proc. Natl Acad. Sci. USA 77, 2542–2545 (1980).

3. Cushman, S. W. & Wardzala, L. J. Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane. J. Biol. Chem. 255, 4758–4762 (1980).

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(Hindemith), WiseWoman

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