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| Untersuchte Arbeit: Seite: 19, Zeilen: 13-21 |
Quelle: Lang et al 2006 Seite(n): 1165, 1166, Zeilen: 1165: last paragraph; 11656: l.col: 8ff |
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| Individuals carrying a certain variant of SGK1 [the combined presence of distinct polymorphisms in intron 6(I6CC) and in exon 8 (E866) have been shown to associated with increased blood pressure. It occurs due to enhanced stimulation of ENaC by SGK1. Moreover, the latter study revealed the role of SGK1 in the hypertension paralleling insulinemia. The outlined SGK1 gene variant may further accelerate intestinal glucose absorption by stimulation of SGLT1 and glucose accumulation in peripheral tissues including fat. Increased SGLT1 activity leads to accelerated intestinal glucose absorption, excessive insulin release, fat deposition, a subsequent decrease of plasma glucose concentration, and triggering of repeated glucose uptake and thus obesity. | [page 1165]
As mentioned above, a certain variant of the SGK1 gene [the combined presence of distinct polymorphisms in intron 6 (I6CC) and in exon 8 (E8CC/CT)] has been shown to be associated with moderately enhanced blood pressure (56, 57). This correlation is presumably due to enhanced stimulation of ENaC by SGK1 in individuals carrying this variant. [page 1166] Moreover, the latter study revealed a relatively strong correlation between insulinemia and blood pressure in individuals carrying the SGK1 gene variant, suggesting a particular role of SGK1 in the hypertension paralleling hyperinsulinemia (339). [...] The outlined SGK1 gene variant may further accelerate intestinal glucose absorption by stimulation of SGLT1 and glucose deposition in peripheral tissues including fat (see above). Enhanced SGLT1 activity, and subsequently accelerated intestinal glucose absorption, may lead to excessive insulin release, fat deposition, a subsequent decrease of plasma glucose concentration, and triggering of repeated glucose uptake and thus obesity (120). [...] |
The source is not given. Note that in the source "the latter study" refers to a different study than in the dissertation of S. J. |
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