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[1.] Sng/Fragment 020 01 - Diskussion
Zuletzt bearbeitet: 2016-05-22 21:42:57 Schumann
Fragment, Gesichtet, SMWFragment, Sajikumar 2005, Schutzlevel sysop, Sng, Verschleierung

Typus
Verschleierung
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 20, Zeilen: 1ff (komplett)
Quelle: Sajikumar 2005
Seite(n): 19-20, Zeilen: 19:22-23 - 20:1-13 - 21:1-3
The induction of late-LTP, on the other hand, requires repeated or stronger trains of high-frequency stimulation. Processes specifically involved in early- and late- phases of LTP require different cellular signaling pathways.

[Fig. 2. The multiple phases of LTP. See text for a detailed description.]

The early-phase of LTP is transient and protein synthesis- independent induced by second messenger cascades, activated by Ca2+ influx, and maintained by activated kinases like CaMKII, tyrosine kinase, (Malenka and Nicoll, 1999;Soderling and Derkach, 2000). Late-LTP begins gradually during the first 2-3 h and can last for 6-10 h in hippocampal slices in vitro and for days to months in vivo (Krug et al., 1989;Frey et al., 1995;Otani and Abraham, 1989;Abraham et al., 2002;Kandel, 2001;Reymann et al., 1985). A further major difference between early-LTP and late-LTP is that late-LTP requires protein synthesis (Krug et al., 1984;Frey et al., 1988;Otani et al., 1989). Application of suppressors of RNA-translation during LTP-induction resulted in a [decremental early-LTP while late-LTP was prevented (Krug et al., 1984;Stanton and Sarvey, 1984;Deadwyler et al., 1987;Abraham and Kairiss, 1988;Frey et al., 1988;Frey et al., 1996;Mochida et al., 2001).]


3. Abraham WC, Kairiss EW (1988) Effects of the NMDA antagonist 2AP5 on complex spike discharge by hippocampal pyramidal cells. Neurosci Lett 89: 36-42.

4. Abraham WC, Logan B, Greenwood JM, Dragunow M (2002) Induction and experience-dependent consolidation of stable long-term potentiation lasting months in the hippocampus. J Neurosci 22: 9626-9634.

36. Deadwyler SA, Dunwiddie T, Lynch G (1987) A critical level of protein synthesis is required for long-term potentiation. Synapse 1: 90-95.

52. Frey U, Frey S, Schollmeier F, Krug M (1996) Influence of actinomycin D, a RNA synthesis inhibitor, on long-term potentiation in rat hippocampal neurons in vivo and in vitro. J Physiol 490: 703-711.

55. Frey U, Krug M, Reymann KG, Matthies H (1988) Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro. Brain Res 452: 57-65.

60. Frey U, Schollmeier K, Reymann KG, Seidenbecher T (1995) Asymptotic hippocampal long-term potentiation in rats does not preclude additional potentiation at later phases. Neuroscience 67: 799-807.

81. Kandel ER (2001) The molecular biology of memory storage: a dialogue between genes and synapses. Science 294: 1030-1038.

90. Krug M, Koch M, Schoof E, Wagner M, Matthies H (1989) Methylglucamine orotate, a memory-improving drug, prolongs hippocampal long-term potentiation. Eur J Pharmacol 173: 223-226.

91. Krug M, Lossner B, Ott T (1984) Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of freely moving rats. Brain Res Bull 13: 39-42.

97. Malenka RC, Nicoll RA (1999) Long-term potentiation--a decade of progress? Science 285: 1870-1874.

107. Mochida H, Sato K, Sasaki S, Yazawa I, Kamino K, Momose-Sato Y (2001) Effects of anisomycin on LTP in the hippocampal CA1: long-term analysis using optical recording. Neuroreport 12: 987-991.

124. Otani S, Abraham WC (1989) Inhibition of protein synthesis in the dentate gyrus, but not the entorhinal cortex, blocks maintenance of long-term potentiation in rats. Neurosci Lett 106: 175-180.

125. Otani S, Marshall CJ, Tate WP, Goddard GV, Abraham WC (1989) Maintenance of long-term potentiation in rat dentate gyrus requires protein synthesis but not messenger RNA synthesis immediately post-tetanization. Neuroscience 28: 519-526.

133. Reymann KG, Malisch R, Schulzeck K, Brodemann R, Ott T, Matthies H (1985) The duration of long-term potentiation in the CA1 region of the hippocampal slice preparation. Brain Res Bull 15: 249-255.

150. Soderling TR, Derkach VA (2000) Postsynaptic protein phosphorylation and LTP. Trends Neurosci 23: 75-80.

155. Stanton PK, Sarvey JM (1984) Blockade of long-term potentiation in rat hippocampal CA1 region by inhibitors of protein synthesis. J Neurosci 4: 3080-3088.

[Seite 19]

The induction of late-LTP, on the other hand, requires repeated or stronger trains of high-frequency stimulation. Processes

[Seite 20]

specifically involved in early- and late- phases of LTP require different cellular signaling pathways (Fig. 2).

[Figure 2. The multiple phases of LTP. See text for a detailed description.]

The early-phase of LTP is transient and protein synthesis- independent, lasting about 2-4 h, induced by second messenger cascades, activated by Ca2+ influx, and maintained by activated kinases like CaMKII, tyrosine kinase, (Malenka and Nicoll, 1999;Soderling and Derkach, 2000). Late-LTP begins gradually during the first 1-3 h and can last for 6-10 h in hippocampal slices in vitro and for days to months in vivo (Krug et al., 1989;Frey et al., 1995;Reymann et al., 1985;Otani et al., 1989;Abraham et al., 2002;Kandel, 2001). A further major difference between early-LTP and late-LTP is that late-LTP requires protein synthesis (Krug et al., 1984;Frey et al., 1988;Otani et al., 1989). Application of suppressors of RNA-translation during LTP-induction resulted in a decremental early-LTP while late-LTP was

[Seite 21]

prevented (Krug et al., 1984;Stanton and Sarvey, 1984;Deadwyler et al., 1987;Abraham and Kairiss, 1988;Frey et al., 1988;Frey et al., 1996;Mochida et al., 2001).


Abraham WC, Kairiss EW (1988) Effects of the NMDA antagonist 2AP5 on complex spike discharge by hippocampal pyramidal cells. Neurosci Lett 89: 36-42.

Abraham WC, Logan B, Greenwood JM, Dragunow M (2002) Induction and experience-dependent consolidation of stable long-term potentiation lasting months in the hippocampus. J Neurosci 22: 9626-9634.

Deadwyler SA, Dunwiddie T, Lynch G (1987) A critical level of protein synthesis is required for long-term potentiation. Synapse 1: 90-95.

Frey U, Frey S, Schollmeier F, Krug M (1996) Influence of actinomycin D, a RNA synthesis inhibitor, on long-term potentiation in rat hippocampal neurons in vivo and in vitro. J Physiol 490: 703-711.

Frey U, Krug M, Reymann KG, Matthies H (1988) Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro. Brain Res 452: 57-65.

Frey U, Schollmeier K, Reymann KG, Seidenbecher T (1995) Asymptotic hippocampal long-term potentiation in rats does not preclude additional potentiation at later phases. Neuroscience 67: 799-807.

Kandel ER (2001) The molecular biology of memory storage: a dialogue between genes and synapses. Science 294: 1030-1038.

Krug M, Koch M, Schoof E, Wagner M, Matthies H (1989) Methylglucamine orotate, a memory-improving drug, prolongs hippocampal long-term potentiation. Eur J Pharmacol 173: 223-226.

Krug M, Lossner B, Ott T (1984) Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of freely moving rats. Brain Res Bull 13: 39-42.

Malenka RC, Nicoll RA (1999) Long-term potentiation--a decade of progress? Science 285: 1870-1874.

Mochida H, Sato K, Sasaki S, Yazawa I, Kamino K, Momose-Sato Y (2001) Effects of anisomycin on LTP in the hippocampal CA1: long-term analysis using optical recording. Neuroreport 12: 987-991.

Otani S, Abraham WC (1989) Inhibition of protein synthesis in the dentate gyrus, but not the entorhinal cortex, blocks maintenance of long-term potentiation in rats. Neurosci Lett 106: 175-180.

Otani S, Marshall CJ, Tate WP, Goddard GV, Abraham WC (1989) Maintenance of long-term potentiation in rat dentate gyrus requires protein synthesis but not messenger RNA synthesis immediately post-tetanization. Neuroscience 28: 519-526.

Reymann KG, Malisch R, Schulzeck K, Brodemann R, Ott T, Matthies H (1985) The duration of long-term potentiation in the CA1 region of the hippocampal slice preparation. Brain Res Bull 15: 249-255.

Soderling TR, Derkach VA (2000) Postsynaptic protein phosphorylation and LTP. Trends Neurosci 23: 75-80.

Stanton PK, Sarvey JM (1984) Blockade of long-term potentiation in rat hippocampal CA1 region by inhibitors of protein synthesis. J Neurosci 4: 3080-3088.

Anmerkungen

Ohne Hinweis auf eine Übernahme.

"Figure 2" ist ebenfalls identisch.

Sichter
(Graf Isolan) Schumann


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