Fandom

VroniPlag Wiki

Sng/Fragment 023 04

< Sng

31.377Seiten in
diesem Wiki
Seite hinzufügen
Diskussion0 Teilen

Störung durch Adblocker erkannt!


Wikia ist eine gebührenfreie Seite, die sich durch Werbung finanziert. Benutzer, die Adblocker einsetzen, haben eine modifizierte Ansicht der Seite.

Wikia ist nicht verfügbar, wenn du weitere Modifikationen in dem Adblocker-Programm gemacht hast. Wenn du sie entfernst, dann wird die Seite ohne Probleme geladen.


Typus
KomplettPlagiat
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 23, Zeilen: 4-16
Quelle: Makhinson et al 1999
Seite(n): 2507-2508, Zeilen: 2507:re.Sp. 47-62 - 2508:li.Sp. 1-2
The Lisman model of LTP (Lisman and McIntyre, 2001) proposes that patterns of synaptic activity that produce low levels of NMDA receptor activation and small increase in intracellular Ca2+ depress synaptic strength via a cascade of protein phosphatase activation (Mulkey et al., 1993). This cascade of protein phosphatase activation is thought to entail a Ca2+- and calmodulin-dependent activation of calcineurin, that dephosphorylates the PP1 regulatory protein inhibitor-1 (Mulkey et al., 1994). Dephosphorylation of inhibitor-1 activates PP1 that in turn dephosphorylates CaMKII. In contrast, stronger levels of NMDA receptor activation and larger increase in intracellular Ca2+ induce LTP by increasing levels of autophosphorylated CaMKII via a simultaneous activation of CaMKII and downregulation of PP1. In the model, a large increase in Ca2+ is thought to suppress PP1 activation by stimulating Ca2+- and calmodulin-sensitive isoforms of adenylate cyclase (AC) and by activating PKA that suppresses PP1 activation by opposing calcineurin-mediated dephosphorylation of inhibitor-1.

94. Lisman JE, McIntyre CC (2001) Synaptic plasticity: a molecular memory switch. Curr Biol 11: R788-R791.

110. Mulkey RM, Endo S, Shenolikar S, Malenka RC (1994) Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression. Nature 369: 486-488.

111. Mulkey RM, Herron CE, Malenka RC (1993) An essential role for protein phosphatases in hippocampal long-term depression. Science 261: 1051-1055.

[Seite 2507]

The Lisman model of LTP (Lisman, 1994) proposes that patterns of synaptic activity that produce low levels of NMDA receptor activation and small increases in intracellular Ca2+ depress synaptic strength via a cascade of protein phosphatase activation (Mulkey and Malenka, 1992; Mulkey et al., 1993, 1994). This cascade of protein phosphatase activation is thought to entail a Ca2+- and calmodulin-dependent activation of calcineurin that dephosphorylates the PP1 regulatory protein inhibitor-1 (Mulkey et al., 1994). Dephosphorylation of inhibitor-1 activates PP1 that in turn dephosphorylates CaMKII. In contrast, stronger levels of NMDA receptor activation and larger increases in intracellular Ca2+ induce LTP by increasing levels of autophosphorylated CaMKII via a simultaneous activation of CaMKII and downregulation of PP1. In the model, a large increase in Ca2+ is thought to suppress PP1 activation by stimulating Ca2+- and calmodulin-sensitive isoforms of AC and by

[Seite 2508]

activating PKA that suppresses PP1 activation by opposing calcineurin-mediated dephosphorylation of inhibitor-1.


Lisman JE (1994) The CaM kinase II hypothesis for the storage of synaptic memory. Trends Neurosci 17:406–412.

Mulkey RM, Malenka RC (1992) Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus. Neuron 9:967–975.

Mulkey RM, Herron CE, Malenka RC (1993) An essential role for protein phosphatases in hippocampal long-term depression. Science 261:1051–1055.

Mulkey RM, Endo S, Shenolikar A, Malenka RC (1994) Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal longterm depression. Nature 369:486–488.

Anmerkungen

Ohne Hinweis auf eine Übernahme.

Sichter
(Graf Isolan) Schumann

Auch bei Fandom

Zufälliges Wiki