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Typus
KomplettPlagiat
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 23, Zeilen: 17-22
Quelle: Blitzer et al 2005
Seite(n): 114, Zeilen: re.Sp. 39-47
A major target for Ca2+ is CaMKII, and among its many actions are the phosphorylation of GluR1 at serine 831 (which increases the channel conductance of the AMPA receptor; (Lee et al., 2000)), and the insertion of the receptor into the postsynaptic membrane through an indirect mechanism; (Hayashi et al., 2000). From a network perspective, the multiple effects of activated CaMKII define it as a ´node´, a point where a signal is split and directed to multiple targets (Schmitt et al., 2005).

66. Hayashi Y, Shi SH, Esteban JA, Piccini A, Poncer JC, Malinow R (2000) Driving AMPA receptors into synapses by LTP and CaMKII: requirement for GluR1 and PDZ domain interaction. Science 287: 2262-2267.

92. Lee HK, Barbarosie M, Kameyama K, Bear MF, Huganir RL (2000) Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature 405: 955-959.

141. Schmitt JM, Guire ES, Saneyoshi T, Soderling TR (2005) Calmodulin-dependent kinase kinase/calmodulin kinase I activity gates extracellular-regulated kinase-dependent long-term potentiation. J Neurosci 25: 1281-1290.

A major target for Ca2+ is Ca2+/calmodulin-dependent kinase type II (CaMKII), a major component of the postsynaptic density. Among its many actions are the phosphorylation of GluR1 at serine 831 (which increases the channel conductance of the AMPA receptor; Lee et al 2000), and the insertion of the receptor into the postsynaptic membrane (through an indirect mechanism; Hayashi et al 2000). From a network perspective, the multiple effects of activated CaMKII define it as a “node,” a point where a signal is split and directed to multiple targets.

Hayashi Y, Shi SH, Esteban JA, Piccini A, Poncer JC, Malinow R (2000): Driving AMPA receptors into synapses by LTP and CaMKII: Requirement for GluR1 and PDZ domain interaction. Science 287:2262–2267.

Lee HK, Barbarosie M, Kameyama K, Bear MF, Huganir RL (2000): Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature 405:955–959.

Anmerkungen

Ohne Hinweis auf eine Übernahme.

Sichter
(Graf Isolan) Schumann

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