Fandom

VroniPlag Wiki

Sng/Fragment 024 14

< Sng

31.371Seiten in
diesem Wiki
Seite hinzufügen
Diskussion0 Teilen

Störung durch Adblocker erkannt!


Wikia ist eine gebührenfreie Seite, die sich durch Werbung finanziert. Benutzer, die Adblocker einsetzen, haben eine modifizierte Ansicht der Seite.

Wikia ist nicht verfügbar, wenn du weitere Modifikationen in dem Adblocker-Programm gemacht hast. Wenn du sie entfernst, dann wird die Seite ohne Probleme geladen.


Typus
Verschleierung
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 24, Zeilen: 14-21
Quelle: Makhinson et al 1999
Seite(n): 2508, Zeilen: li.Sp. 53-62
Though PKA was initially identified as having an important signaling role in the protein synthesis-dependent late stages of LTP (Frey et al., 1993), more recent evidence suggests that PKA also provides a mechanism for suppression of protein phosphatase activation in the early stages of LTP induction (Blitzer et al., 1995;Winder et al., 1998;Blitzer et al., 1998). Activation of the cAMP-PKA signaling pathway regulates both activity-dependent changes in synaptic strength and CaMKII phosphorylation in a chemical LTP induction protocol (Yamamori et al., 2004).

23. Blitzer RD, Connor JH, Brown GP, Wong T, Shenolikar S, Iyengar R, Landau EM (1998) Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. Science 280: 1940-1942.

24. Blitzer RD, Wong T, Nouranifar R, Iyengar R, Landau EM (1995) Postsynaptic cAMP pathway gates early LTP in hippocampal CA1 region. Neuron 15: 1403-1414.

54. Frey U, Huang YY, Kandel ER (1993) Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science 260: 1661-1664.

171. Winder DG, Mansuy IM, Osman M, Moallem TM, Kandel ER (1998) Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin. Cell 92: 25-37.

174. Yamamori E, Asai M, Yoshida M, Takano K, Itoi K, Oiso Y, Iwasaki Y (2004) Calcium/calmodulin kinase IV pathway is involved in the transcriptional regulation of the corticotropin-releasing hormone gene promoter in neuronal cells. J Mol Endocrinol 33: 639-649.

Although PKA was initially identified as having an important signaling role in the protein synthesis-dependent late stages of LTP (Frey et al., 1993; Matthies and Reymann, 1993), more recent evidence suggests that PKA also provides a mechanism for suppression of protein phosphatase activation in the early stages of LTP induction (Blitzer et al., 1995, 1998; Thomas et al., 1996; Winder et al., 1998). Consistent with this notion, our results show that activation of the cAMP–PKA signaling pathway regulates both activity-dependent changes in synaptic strength and CaMKII phosphorylation in a chemLTP induction protocol.

Blitzer RD, Wong T, Nouranifar R, Iyengar R, Landau EM (1995) Postsynaptic cAMP pathway gates early LTP in the hippocampal CA1 region. Neuron 15:1403–1414.

Blitzer RD, Connor JH, Brown GP, Wong T, Shenolikar S, Iyengar R, Landau EM (1998) Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. Science 280:1940 –1943.

Frey U, Huang Y-Y, Kandel ER (1993) Effects of cAMP simulate a late phase of LTP in hippocampal CA1 neurons. Science 260:1661–1664.

Matthies H, Reymann KG (1993) Protein kinase A inhibitors prevent the maintenance of hippocampal long-term potentiation. NeuroReport 4:712–714.

Thomas MJ, Moody TD, Makhinson M, O’Dell TJ (1996) Activity-dependent b-adrenergic modulation of low frequency stimulation induced LTP in the hippocampal CA1 region. Neuron 17:475– 482.

Winder DG, Mansuy IM, Osman M, Moallem TM, Kandel ER (1998) Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin. Cell 92:25–37.

Anmerkungen

Ohne Hinweis auf eine Übernahme.

Sichter
(Graf Isolan) Schumann

Auch bei Fandom

Zufälliges Wiki