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Typus
KomplettPlagiat
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 34, Zeilen: 15-23
Quelle: Sajikumar 2005
Seite(n): 35, Zeilen: 35:14-17.20-25 - 36:1.
As a possible solution to this targeting problem, the 'synaptic tag hypothesis' (Frey and Morris, 1997;Frey and Morris, 1998a) proposed that the persistence of LTP is mediated by the intersection of two dissociable events. The first event involves the generation of a local ‘synaptic tag’ at specific synapses in association with and perhaps causally related to the induction of LTP. The second involves the production and diffuse distribution of ‘plasticity-related proteins’ (PRPs) that are captured and utilised only at those synapses possessing a tag.

The ´synaptic tagging´ hypothesis describes a mechanism, how input specificity is achieved during a protein synthesis-dependent stage (Frey and Morris, 1997;Frey and Morris, 1998a;Frey and Morris, 1998b;Martin and Kosik, 2002).


57. Frey U, Morris RG (1997) Synaptic tagging and long-term potentiation. Nature 385: 533-536.

58. Frey U, Morris RG (1998a) Synaptic tagging: implications for late maintenance of hippocampal long-term potentiation. Trends Neurosci 21: 181-188.

59. Frey U, Morris RG (1998b) Weak before strong: dissociating synaptic tagging and plasticity-factor accounts of late-LTP. Neuropharmacology 37: 545-552.

101. Martin KC, Kosik KS (2002) Synaptic tagging -- who's it? Nat Rev Neurosci 3: 813-820.

[Seite 35]

The ´synaptic tagging´ hypothesis describes a mechanism, how input specificity is achieved during a protein synthesis-dependent stage (Frey and Morris, 1997;Frey and Morris, 1998a;Frey and Morris, 1998b;Martin and Kosik, 2002). [...]

The synaptic tag hypothesis (Frey and Morris, 1997;Frey and Morris, 1998a) proposed that the persistence of LTP is mediated by the intersection of two dissociable events. The first event involves the generation of a local ‘synaptic tag’ at specific synapses in association with and perhaps causally related to the induction of LTP. The second involves the production and diffuse distribution of ‘plasticity related proteins’ (PRPs) that are captured and

[Seite 36]

utilized only at those synapses possessing a tag.


Frey U, Morris RG (1997) Synaptic tagging and long-term potentiation. Nature 385: 533-536.

Frey U, Morris RG (1998a) Synaptic tagging: implications for late maintenance of hippocampal long-term potentiation. Trends Neurosci 21: 181-188.

Frey U, Morris RG (1998b) Weak before strong: dissociating synaptic tagging and plasticity-factor accounts of late-LTP. Neuropharmacology 37: 545-552.

Martin KC, Kosik KS (2002) Synaptic tagging -- who's it? Nat Rev Neurosci 3: 813-820.

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