It is a pleasure to thank those who gave their support in different ways to complete this work and I would like to convey my heartfelt gratitude and sincere appreciation.
First and foremost I would like to express my sincere thanks to my supervisor, Prof. Dr. Julietta Uta Frey, for the guidance and support that she provided throughout the course of this work. Moreover her encouragement, helpfulness and moral support helped me, not only to overcome but also to persevere and excel, which has increased my confidence and abilities as a researcher.
I am especially grateful to Dr. Sreedharan Sajikumar for all kinds of encouragement and support which helped me to progress every time.
I am highly indebted to Manuela Homeyer, who made everything easier for me by her timely help, and co-operation during the entire period of this work.
I express my sincere thanks to Dr. Volker Korz for all his help and scientific discussions.
I wish to acknowledge the help and valuable suggestions given to me by Dr. Thomas Behnisch, Dr. Sabine Frey, Dr. Anna Karpova, Dr. Tariq Ahmed and Dr. Hadir Hassan.
I would like to thank Dr. Anoopkumar Thekkuveettil, Dept. of Molecular Medicine, SCTIMST, Thiruvananthapuram, Kerala, India, for guiding me into the field of Neuroscience.
I express my sincere thanks to Diana Koch, Gusalija Behnicsh, Silvia Vieweg, Sybille Tschorn, Sabina Opitz, Diana Marenda, Jeanette Maiwald and Jürgen Buggert for their excellent technical assistance and co-operation during the course of this study.
I would like to thank my colleagues Dasha, Marina, Sergey, Schukrat, Frank and all my friends who cooperated with me during the period of this work.
And last, but most of all, to my parents, and sisters, I owe everything; they sustain me in all that I do and it is to them that this work is dedicated with love.
Finally, my best thanks of all goes to God, who has always been there for me.
I feel extremely fortunate to have the privilege of working under the inspiring supervision of Prof. Dr. Julietta Uta Frey. I sincerely thank her for the constant support, encouragement and constructive criticisms. Her unstinted guidance and monitoring of this work has enabled me to take the right direction.
I am highly grateful to Sabine Opitz for her excellent technical assistance during the initial period of this work.
I am highly indebted to Manuela Homeyer for her timely help, and co-operation extended to me during the entire period of this work.
I wish to acknowledge the help and valuable suggestions given to me by Dr. Maxim Sokolov, Dr. Volker Korz, Dr. Sabine Frey, Dr. Thomas Behnisch, Dr. Tariq Ahmed and Dr. Anna Karpova.
I express my sincere thanks to Gusalija Behnisch, Sybille Tschorn, Diana Koch and Silvia Vieweg for their excellent technical assistance and co-operation during the course of this study.
I am specially thankful to all of my colleagues especially to Sheeja Navakkode for her help and scientific discussions.
The constant support and encouragement extended to me by Prof. Dr. T. Ramakrishna and Prof. Dr. V. K. Sasidharan is acknowledged here with great fondness and sincerity.
Above all I wish to express my deep sense of gratitude and special indebtedness to my parents, brothers and sister for their love, tolerance and moral support, which made me possible to stand at this point of life.