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Quelle: Waelzlein 2007
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1.3. Diagnosis and treatment of gliomas

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Fig. 1.3. MRT of a human brain, revealing a glioblastoma multiforme

(rad.usuhs.mil/rad/who/zs224248)

If a neurological examination points to a brain tumor, additional testings will be made. These mainly include scans like magnetic resonance imaging (MRI, Fig. 1.3.), computer tomography (CT) or positron emission tomography (PET). In most cases therapy starts with surgical removal of the tumor. Since for the tumor patient gliomas may be located in brain areas which are of vital importance and the surgical removal of these neoplasms can be much more difficult than removing a tumor in other parts of the body. Even if the surgery is successful it has to be assumed that tumor cells have already spread throughout the brain and may be the source for tumor relapses.

One of the main properties of glioma cells is their invasive behaviour, which also signifies the biggest challenge regarding therapy (Holland, E.C. et al, 2001; Kleihues, P et al, 1995). Therefore combined radiochemotherapy typically follows surgery. Conventional radiation therapy uses X- or gamma-rays but also other types of radiation are available. At present, the standard chemotherapeutic is temozolomide (Temodal®). Its cytotoxicity is due to alcylation of the nucleobase guanine.

1.3.3. Diagnosis and treatment of glioblastoma

Scr 011a source.png

Fig. 1.4. MRT of a human brain, revealing a glioblastoma multiforme

(rad.usuhs.mil/rad/who/zs224248)

If a neurological examination points to a brain tumour, additional tests will be made. These mainly include scans like magnetic resonance imaging (MRI, fig. 1.4.), computer tomography (CT) or positron emission tomography (PET). In most cases therapy starts with surgical removal of the tumour. Due to the limited space in the brain this is much more difficult than removing a tumour in other parts of the body. Even if the surgery is

[Seite 15]

successful it has to be assumed that tumour cells have already spread throughout the brain and may be the source for tumour relapses.

One of the main properties of glioma cells is their invasive behaviour, which also signifies the biggest challenge regarding therapy (31;41). Therefore combined radiochemotherapy typically follows surgery. At present, the standard chemotherapeutic is temozolomide (Temodal®); its cytotoxicity is due to alcylation of the nucleobase guanine.


31. Holland,E.C. 2001. Gliomagenesis: genetic alterations and mouse models. Nat.Rev.Genet. 2:120-129.

41. Kleihues,P., Soylemezoglu,F., Schauble,B., Scheithauer,B.W., and Burger,P.C. 1995. Histopathology, classification, and grading of gliomas. Glia 15:211-221.

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