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Quelle: Dirks 2008 Seite(n): 2819, Zeilen: 43ff |
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CD133 positive human glioblastoma cells were shown to be resistant to radiation therapy, retaining a clonogenic and tumorigenic potential. CD133 positive cells increase in number after irradiation of glioblastoma cells in culture and in tumors growing in vivo. The CD133 positive cells undergo similar DNA damage to those of their CD133 negative counterparts, but they show a better ability to repair strand breaks, through a more potent activation of DNA damage checkpoint mechanisms (Bao, S. et al, 2006). | In work by the Rich group,24 CD133+ humanglioblastoma cells were shown to be resistant to radiation therapy, retaining a clonogenic and tumorigenic potential. CD133+ cells increase in number after irradiation of glioblastomas cells in culture and in tumors growing in vivo. The CD133+ cells undergo similar DNA damage to those of their CD133– counterparts, but they show a better ability to repair strand breaks, through a more potent activation of DNA-damage checkpoint mechanisms.
24. Bao S, Wu Q, McLendon RE, et al: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756-760, 2006 |
Ein Verweis auf die Quelle fehlt. Bao, S. et al, 2006 enthält den Text nicht. |
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