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Untersuchte Arbeit:
Seite: 18, Zeilen: 12-18
Quelle: Dirks 2008
Seite(n): 2919, Zeilen: 0
Promotion of tumor stem-cell differentiation may be an important strategy for treatment of brain tumor stem cells. Bone morphogenic proteins (BMPs), which normally induce astrocyte differentiation from normal neural precursors, have been shown to promote glioblastoma cell differentiation in vitro and in vivo. Most importantly, recombinant BMPs induce the suppression of glioblastoma tumorigenicity in vivo, possibly though promotion of the differentiation cancer stem cells in the tumor (Piccirillo, S.G., et al 2006). Promotion of tumor stem-cell differentiation may be an important strategy for treatment of brain tumor stem cells. Vescovi et al26 have shown that bone morphogenic proteins (BMPs), which normally induce astrocyte differentiation from normal neural precursors, have been shown to promote glioblastoma cell differentiation in vitro and in vivo. Most importantly, BMPs induce the suppression of glioblastoma tumorigenicity in vivo, possibly though promotion of the differentiation of restricted tumor progenitors or by direct action on the most primitive cell (the cancer stem cell) in the tumor.

26. Piccirillo SG, Reynolds BA, Zanetti N, et al: Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 444:761-765, 2006

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Piccirillo, S.G., et al 2006 enthält den Text nicht.

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