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Typus
Verschleierung
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 39, Zeilen: 1-17
Quelle: Wernsmann et al 2006
Seite(n): 1108, Zeilen: r.col: 28-47
In line with this, physiological studies have disclosed the existence of powerful inhibition in the entorhinal cortex (Finch et al., 1986; Jones & Buhl, 1993; Funahashi & Stewart, 1998), which may act to abort the propagation of SD.

In addition, some studies indicated relative difficulties of SD occurrence in the hippocampus compared with the entorhinal cortex (Dalby & Mody, 2003; Faria & Mody, 2004). The failure of cortical SD to spread to the hippocampus was reported earlier (Fifkova, 1964). The release of glutamate is essential to the propagation of cortical SD (Van Harreveld & Fifkova, 1973). Several studies have shown that glutamate acts via NMDA receptors during the generation and propagation of SD (Mody et al., 1987; Gorji, 2001). The NMDA receptors are assembled from NR1 subunits and at least one subtype of the four members of the NR2(A–D) subunits family. NR2B subunits are essential to the generation and propagation of SD in the entorhinal cortical slices (Faria & Mody, 2004). The physiological characteristics and possibly the localization of NR2B subunits at synapses differ between the entorhinal cortex and the hippocampus (Gordey et al., 2001; Faria & Mody, 2004), which, in turn, may influence SD penetration into the hippocampus.

Consistent with this, physiological studies have disclosed the existence of powerful inhibition in the entorhinal cortex (Finch et al., 1986; Jones & Buhl, 1993; Funahashi & Stewart, 1998), which may act to abort the propagation of SD.

Furthermore, some studies indicated a relative resistance of SD occurrence in the hippocampus compared with entorhinal cortex (Dalby & Mody, 2003; Faria & Mody, 2004). The failure of cortical SD to propagate to the hippocampus was reported earlier (Fifkova, 1964). The release of glutamate is essential to the propagation of cortical SD (Van Harreveld & Fifkova, 1973). Several studies have shown that glutamate acts via NMDA receptors during the generation and propagation of SD (Mody et al., 1987; Gorji, 2001). The NMDA receptor is a heterotetramer assembled from NR1 subunits and at least one subtype of the four members of the NR2(A–D) subunits family. NR2B subunits are essential to the generation and propagation of SD in entorhinal cortical slices (Faria & Mody, 2004). The physiological characteristics and possibly the localization of NR2B subunits at synapses differ between the entorhinal cortex and the hippocampus (Gordey et al., 2001; Faria & Mody, 2004), which, in turn, may influence SD penetration into the hippocampus.

Anmerkungen

The source is not mentioned here. It will be mentioned in passing in the next paragraph.

Sichter
(Hindemith) Agrippina1

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