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Ectopic expression of the homeobox gene Cdx2 is the key transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia; a novel mechanism in AML

von Dr. Vpr

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[1.] Vpr/Fragment 005 09 - Diskussion
Zuletzt bearbeitet: 2014-04-04 23:00:43 Hindemith
BauernOpfer, Fragment, Gesichtet, Jamieson et al 2004, SMWFragment, Schutzlevel sysop, Vpr

Typus
BauernOpfer
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 5, Zeilen: 9-22
Quelle: Jamieson et al 2004
Seite(n): 532, Zeilen: figure
05a diss Vpr.png

Figure 3. Oncogene hierarchy and role of self-renewal in the pathogenesis of leukemias.

A. Normal myelopoiesis is distinguished by the orderly differentiation of HSC, which are the only cells with self-renewal capacity, into committed myeloid progenitors and their respective terminally differentiated progeny. B. Chronic diseases, such as chronic phase CML, are associated with preleukemic events that result in increased survival and proliferation within the stem and myeloid progenitor populations but continued production of terminally differentiated progeny. Acquisition of BCR-ABL, overexpression of BCL2, and inactivation of JunB expression are examples of such events that initially take place in HSC. C and D: Acute diseases such as blast crisis CML and AML are marked by acquisition of self-renewal capacity by progenitors that normally lack it or by enhanced self-renewal in HSC. β-catenin activation during the progression of CML to blast crisis is an example of such a leukemogenic event occurring in myeloid progenitors. MOZ-TIF2 and MLL-ENL are AML-associated translocation products that may enhance HSC self-renewal or endow myeloid progenitors with self-renewal potential. Together with a subsequent block in differentiation, these leukemogenic [events result in the accumulation of immature blast progeny and development of AML at either the HSC or myeloid progenitor stage (Figure adapted from Jamieson et. al., 2004b) .]

05a source Vpr.png

Figure 1. Oncogene hierarchy and role of self-renewal in pathogenesis of leukemias

A: Normal myelopoiesis is distinguished by the orderly differentiation of hematopoietic stem cells (HSC), which are the only cells with self-renewal capacity, into committed myeloid progenitors and their respective terminally differentiated progeny.

B: Chronic diseases, such as chronic phase CML, are associated with preleukemic events that result in increased survival and proliferation within the stem and myeloid progenitor populations but continued production of terminally differentiated progeny. Acquisition of BCR-ABL, overexpression of Bcl2, and inactivation of JunB expression are examples of such events that initially take place in HSC.

C and D: Acute diseases such as blast crisis CML and AML are marked by acquisition of self-renewal capacity by progenitors that normally lack it or by enhanced self-renewal in HSC. β-catenin activation during the progression of CML to blast crisis is an example of such a leukemogenic event occurring in myeloid progenitors. MOZ-TIF2 and MLL-ENL are AML-associated translocation products that may enhance HSC self-renewal or endow myeloid progenitors with self-renewal potential. Together with a subsequent block in differentiation, these leukemogenic events result in the accumulation of immature blast progeny and development of AML at either the HSC or myeloid progenitor stage.

Anmerkungen

The source is mentioned: "Figure adapted from Jamieson et. al., 2004b", but is not clear to the reader that "adapted from" actually means "copied from" and that also the very extensive figure caption has been copied 1-to-1.

Sichter
(Hindemith) Schumann


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