Vpr/012

Ectopic expression of the homeobox gene Cdx2 is the key transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia; a novel mechanism in AML

von Dr. Vijay Pal Singh Rawat

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[1.] Vpr/Fragment 012 06 - Diskussion Zuletzt bearbeitet: 2017-01-27 21:22:01 WiseWoman

Fragment, Gesichtet, SMWFragment, Schutzlevel sysop, Verschleierung, Vpr, Yuasa 2003

Typus Verschleierung

Bearbeiter Hindemith

Gesichtet

Untersuchte Arbeit: Seite: 12, Zeilen: 6-9

Quelle: Yuasa 2003 Seite(n): 593, 594, Zeilen: 593: r.col: 11-14 ; 594: figure caption

Cdx2 expression starts in the proximal intestine and decreases posteriorly, whereas Cdx1 expression starts in the distal intestine with overlapping expression of Cdx1 and Cdx2 in the midgut (Fig.8). Figure 8. Regional expression of transcription factors in the developing gut. The transcription factors shown on the right have been mapped to specific regions of the endoderm, as shown on the left. There is a presumed rule of expression patterns of HOX genes in the developing gut. Each subdomain of the developing digestive tract (foregut, midgut and hindgut) seems to have a different HOX code: Cdx2 expression starts in the proximal intestine and decreases (lightening bar) posteriorly, whereas Cdx1 expression starts in the distal intestine and decreases anteriorly. Pdx1 expression has been observed in the antrum and duodenum. Sox2 is expressed from the pharynx to the stomach.

[page 593] CDX2 expression starts in the proximal intestine and decreases posteriorly, whereas CDX1 expression starts in the distal intestine, and they overlap in the midgut. [page 594] Figure 2 Regional expression of transcription factors in the developing gut. The transcription factors shown on the right have been mapped to specific regions of the endoderm, as shown on the left. There is a presumed rule of expression patterns of HOX genes in the developing gut. Each subdomain of the developing digestive tract (foregut, midgut and hindgut) seems to have a different HOX code8,12,13. CDX2 expression starts in the proximal intestine and decreases (lightening bar) posteriorly, whereas CDX1 expression starts in the distal intestine and decreases anteriorly16. PDX1 expression has been observed in the antrum and duodenum17. SOX2 is expressed from the pharynx to the stomach27. [...]

Anmerkungen The source is not mentioned anywhere in the thesis.

Sichter (Hindemith) Schumann

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