Ectopic expression of the homeobox gene Cdx2 is the key transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia; a novel mechanism in AML
von Dr. Vijay Pal Singh Rawat
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| [1.] Vpr/Fragment 024 03 - Diskussion Zuletzt bearbeitet: 2014-04-05 19:38:57 Hindemith | Bohlander 2005, Fragment, Gesichtet, SMWFragment, Schutzlevel sysop, Verschleierung, Vpr |
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Quelle: Bohlander 2005 Seite(n): 167, Zeilen: l.col: 30-37 |
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| The t(12;13)(p13;q12) translocation was discovered by Chase and coworkers in 1999 in a rare case of AML and was shown to result in the novel fusion between ETV6 and caudal related homeobox gene CDX2 (Chase et. al., 1999). Interestingly, it was noted at that time that a non-rearranged CDX2 mRNA was expressed at high levels in this patient. Normally, CDX2 is not expressed in adult hematopoiesis.
Chase, A., Reiter, A., Burci, L., Cazzaniga, G., Biondi, A., Pickard, J., Roberts, I. A., Goldman, J. M., and Cross, N. C. (1999). Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13;q12). Blood 93, 1025-1031. |
The t(12;13)(p13;q12) translocation found in rare cases of AML was shown to result in one case in the fusion of ETV6 with the caudal related homeobox gene CDX2 [69]. The breakpoint in this case was after exon 2 of ETV6. Interestingly, it was noted at that time that a non-rearranged CDX2 mRNA was expressed at high levels in this patient. Normally, CDX2 is only expressed in the epithelia of the gut and in early development.
[69] Chase A, Reiter A, Burci L, Cazzaniga G, Biondi A, Pickard J, et al. Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t(12;13)(p13;q12). Blood 1999;93:1025–31. |
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