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Seite: 19, Zeilen: 13-26
Quelle: Bohlander 2005
Seite(n): 163, Zeilen: l.col: 25ff
ETV6 (ETS variant gene 6) was originally called TEL, for translocation ets leukemia gene. ETV6 is a member of the ets (E-26 transforming specific) family of transcription factors. All ets family proteins share a conserved protein domain of about 88 amino acids in length, the so called ets domain (see Figure 10) (Bohlander SK 2005). The ets domain is a sequence specific DNA binding domain but it also mediates protein-protein interaction. The other evolutionarily conserved domain is the N terminally located pointed or SAM (sterile alpha motif) domain in the 652 amino acids of ETV6 (Bohlander SK 2005). This domain is also called HLH (helix loop helix) domain. It is found in yeast proteins and has been shown to be involved in homo and heterodimerization of transcription factors and in signal transducing proteins (e.g. of the MAPK pathway) (Fig.10). ETV6 contains two alternative translational start codons (position 1 and position 43), leading to the expression of two isoforms of ETV6. [...], which they called TEL (Translocation Ets Leukemia gene). TEL was later renamed to ETV6 (ets variant gene 6) by the nomenclature commission [...]

[...]

ETV6 is a member of the ets (E-26 transforming specific) family of transcription factors. All ets family proteins share a very conserved protein domain of about 88 amino acids in length the so-called ets domain (see Fig. 1). The ets domain is a sequence specific DNA binding domain but it also mediates protein-protein interaction, it is evolutionarily highly conserved and found in invertebrates such as Drosophila and C. elegans [4,5].

The other evolutionarily conserved domain in the 652 amino acids of ETV6 is the N-terminally located pointed or sterile alpha motif (SAM) domain whose 3D structure has recently been elucidated [6,7]. This domain is also called HLH domain and is even more highly conserved in evolution and found in many ets family member. It is found in yeast proteins and has been shown to be involved in homo- and heterodimerization in transcription factors and in signal transducing proteins (e.g. of the MAPK pathway) [8]. ETV6 contains two alternative translationals start codons (position 1 and position 43) leading to the expression of two isoforms of ETV6.


[4] Oikawa T, Yamada T. Molecular biology of the Ets family of transcription factors. Gene 2003;303:11–34.

[5] Wasylyk B, Hahn SL, Giovane A. The Ets family of transcription factors. Eur J Biochem 1993;211:7–18.

[6] Tran HH, Kim CA, Faham S, Siddall MC, Bowie JU. Native interface of the SAM domain polymer of TEL. BMC Struct Biol 2002;2:5.

[7] Kim CA, Phillips ML, Kim W, Gingery M, Tran HH, Robinson MA, et al. Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression. EMBO J 2001;20:4173–82.

[8] Grimshaw SJ, Mott HR, Stott KM, Nielson PR, Evetts KA, Hopkins LJ, et al. Structure of the sterile alpha motif (SAM) domain of the Saccharomyces cerevisiae mitogen-activated protein kinase pathway-modulating protein STE50 and analysis of its interaction with the STE11 SAM. J Biol Chem 2004;279:2192–201.

Anmerkungen

The source is mentioned twice, but it is not clear to the reader that the entire paragraph is taken from. In particular the passage after the second reference to the source is impossible to detect for the reader as a text of Bohrlander. Most likely, however, the immediate source has been different, see Vpr/Fragment_019_01

Note that the expression "the other evolutionarily conserved domain" is curious in the thesis, as there is no first "evolutionarily conserved domain". In the source there is a first one discussed, but this part was not copied.

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