Fandom

VroniPlag Wiki

Vpr/Fragment 004 23

< Vpr

31.268Seiten in
diesem Wiki
Seite hinzufügen
Diskussion0 Share

Störung durch Adblocker erkannt!


Wikia ist eine gebührenfreie Seite, die sich durch Werbung finanziert. Benutzer, die Adblocker einsetzen, haben eine modifizierte Ansicht der Seite.

Wikia ist nicht verfügbar, wenn du weitere Modifikationen in dem Adblocker-Programm gemacht hast. Wenn du sie entfernst, dann wird die Seite ohne Probleme geladen.


Typus
BauernOpfer
Bearbeiter
SleepyHollow02
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 4, Zeilen: 23-31
Quelle: Reya et al 2001
Seite(n): 107, Zeilen: left col., 23-28 - right col. 1-7
If dysregulation of signaling pathways that normally regulate stem cell selfrenewal leads to tumorigenesis, then stem cells themselves might be the target of transformation in certain types of cancer. There are two reasons to think that this hypothesis may be correct: first, because stem cells have the machinery for self-renewal already activated, maintaining this activation may be simpler than turning it on de novo in a more differentiated cell; that is, fewer mutations may be required to maintain self-renewal than to activate it ectopically. Secondly, stem cells often persist for long periods of time, instead of dying like many mature cells in highly proliferative tissues. This means that there is a much greater [opportunity for mutations to accumulate in individual stem cells than in most mature cell types.] If the signalling pathways that normally regulate stem cell selfrenewal lead to tumorigenesis when dysregulated, then are stem cells themselves the target of transformation in certain types of cancer28,29? There are two reasons to think that this may be the case. First, because stem cells have the machinery for self-renewal already activated, maintaining this activation may be simpler than turning it on de novo in a more differentiated cell; that is, fewer mutations may be required to maintain self-renewal than to activate it ectopically. Second, by self-renewing, stem cells often persist for long periods of time, instead of dying after short periods of time like many mature cells in highly proliferative tissues. This means that there is a much greater opportunity for mutations to accumulate in individual stem cells than in most mature cell types (Fig. 3).
Anmerkungen

The source is mentioned two sentences further down, but it is not clear that Reya et al are quoted literally here.

Sichter
(SleepyHollow02) Schumann

Auch bei Fandom

Zufälliges Wiki