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Hindemith
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Untersuchte Arbeit:
Seite: 6, Zeilen: 3-11
Quelle: Abate-Shen 2002
Seite(n): 777, Zeilen: r.col: 2ff
The homeobox (HB) was first identified in the 1980s as a sequence motif that was shared among Drosophila homeotic genes (the HOM-C complex), where they play a key role in embryonic differentiation along the anterior–posterior (ap) axis, and is now known to be present in many genes in virtually all eukaryotic species (Stein et. al., 1996). It is estimated that the human genome contains at least 200 homeobox genes (Tupler et. al., 2001), of which only 39 are members of the HOX family. Unlike the HOM-C/HOX genes, which are organized in gene clusters, most homeobox genes are dispersed throughout the genome (Abate-Shen, 2002).

Abate-Shen, C. (2002). Deregulated homeobox gene expression in cancer: cause or consequence? Nat Rev Cancer 2, 777-785.

Stein, S., Fritsch, R., Lemaire, L., and Kessel, M. (1996). Checklist: vertebrate homeobox genes. Mech Dev 55, 91-108.

Tupler, R., Perini, G., and Green, M. R. (2001). Expressing the human genome. Nature 409, 832-833.

The homeobox was first identified in the 1980s as a sequence motif that was shared among Drosophila HOMEOTIC GENES (the HOM-C complex), and is now known to be present in many genes in virtually all eukaryotic species1,2. [...] It is estimated that the human genome, for example, includes at least 200 homeobox genes3, of which only 39 are members of the HOX family. Unlike the HOM-C/HOX genes, which are organized on chromosome clusters, most homeobox genes are dispersed throughout the genome.

1. Duboule, D. (ed.) Guidebook to the Homeobox Genes (Oxford Univ. Press, New York, 1994).

2. Stein, S., Fritsch, R., Lemaire, L. & Kessel, M. Checklist: vertebrate homeobox genes. Mech. Dev. 55, 91–108 (1996).

3. Tupler, R., Perini, G. & Green, M. R. Expressing the human genome. Nature 409, 832–833 (2001).

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