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Typus
BauernOpfer
Bearbeiter
Hindemith
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 9, Zeilen: 1-10
Quelle: Buske et al 2001
Seite(n): 2286, 2287, Zeilen: 2286:1f., l.col: 8-17; 2287: l.col: 8-11
Leukemic blasts from many patients with acute myeloid leukemia (AML) show an aberrant pattern of HOXA10 expression, further supporting the concept that dysregulated HOX gene expression may be a general feature of this malignancy (Kawagoe et. al., 1999; Lawrence et. al., 1995). Overexpression of HOXA10 in the progeny of human cord blood or fetal liver cells perturbs human lymphomyelopoiesis in vitro and in vivo (Buske et. al., 2001). Notably, the expression of HOXA9 has been identified as one of the most consistent diagnostic markers of AML in humans and as the only single gene expression marker of more than 6800 cDNAs tested by DNA micro-array analysis that correlated with clinical outcome (Golub et. al., 1999).

Buske, C., Feuring-Buske, M., Antonchuk, J., Rosten, P., Hogge, D. E., Eaves, C. J., and Humphries, R. K. (2001). Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo. Blood 97, 2286-2292.

Golub, T. R., Slonim, D. K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J. P., Coller, H., Loh, M. L., Downing, J. R., Caligiuri, M. A., et al. (1999a). Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286, 531-537.

Kawagoe, H., Humphries, R. K., Blair, A., Sutherland, H. J., and Hogge, D. E. (1999). Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells. Leukemia 13, 687-698.

Lawrence, H. J., Sauvageau, G., Ahmadi, N., Lopez, A. R., LeBeau, M. M., Link, M., Humphries, K., and Largman, C. (1995). Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells. Exp Hematol 23, 1160-1166.

Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo

[...]

[...] More recently, we and others have shown that the leukemic blasts from many patients with acute myeloid leukemia (AML) show an aberrant pattern of HOXA10 expression, further supporting the concept that dysregulated HOX gene expression may be a general feature of this malignancy.8,9 Notably, the expression of HOXA9 has been identified as one of the most consistent diagnostic markers of AML in humans and as the only single gene expression marker of more than 6800 cDNAs tested by DNA micro-array analysis that correlated with clinical outcome.10

[page 2287]

We focused on the analysis of the effects of HOXA10 overexpression in the progeny of human cord blood or fetal liver cells [...]


8. Lawrence HJ, Sauvageau G, Ahmadi N, et al. Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells. Exp Hematol. 1995;23:1160- 1166.

9. Kawagoe H, Humphries RK, Blair A, Sutherland HJ, Hogge DE. Expression of HOX genes, Hoxcofactors, and Mll in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells. Leukemia.1999; 13:687-698.

10. Golub TR, Slonim DK, Tamayo P, et al. Molecular classification of cancer: class discovery and class prediction by gene expressing monitoring. Science. 1999;286:531-537.

Anmerkungen

The source is mentioned, but the copied text continues after the reference to Buske and in the way the reference is given the reader must assume it is given only for the statement "Overexpression of HOXA10 in the progeny of human cord blood or fetal liver cells perturbs human lymphomyelopoiesis in vitro and in vivo".

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(Hindemith) Schumann

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