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SleepyHollow02
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Untersuchte Arbeit:
Seite: 11, Zeilen: 1-12
Quelle: Owens and Hawley 2002
Seite(n): 3670, Zeilen: l.col., 37-50 - r.col: 1
1.3.2.1 TALE homeobox genes

Members of the TALE family of non-HOX HD cofactor proteins, which include PBX, MEIS, and PREP1/KNOX1 proteins, are distinguished from other HD proteins by the inclusion of an additional three amino acids between α- helices 1 and 2 within the HD. Evidence from mouse models and human leukemic cells has indicated that inappropriate expression of TALE cofactors with certain HD proteins may contribute to leukemic transformation, while overexpression of TALE cofactors alone does not lead to disease development. One of these proteins, PBX1, has oncogenic potential in the form of a fusion protein with E2A. The PBX1 gene was originally identified at the breakpoint of the t(1;19) translocation found in 10 to 20% of childhood pre-B-cell ALL (Shikano et. al., 1999).

Members of the TALE family of non-HOX HD cofactor proteins, which include PBX, MEIS, and PREP1/KNOX1 proteins, are distinguished from other HD proteins by the inclusion of an additional three amino acids between α-helices 1 and 2 within the HD. Evidence from mouse models and human leukemic cells has indicated that inappropriate expression of TALE cofactors with certain HD proteins may contribute to leukemic transformation, while overexpression of TALE cofactors alone does not lead to disease development. However, as noted above and discussed in detail below, one of these proteins, PBX1, has oncogenic potential in the form of a fusion protein with E2A. The PBX1 gene was originally identified at the breakpoint of the t(1;19) translocation found in childhood pre-B-cell ALL [29, 30]

29 Kamps MP, Murre C, Sun XH et al. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell 1990;60:547-555.

30 Nourse J, Mellentin JD, Galili N et al. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell 1990;60:535-545.

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