Genetic Diversity of Helicobacter pylori Isolates in Sudan
von Dr. Wael Faroug Elamin
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| As with several other bacterial species, including Neisseria spp. and Streptococcus pneumoniae, H. pylori is naturally competent for genetic transformation in vitro (Nedenskov-Sorensen et al., 1990). This property allows for the uptake of exogenous DNA, which may subsequently replicate, in the case of plasmids, or incorporate into the chromosome by homologous recombination. In addition to genetic exchange via transformation, H. pylori strains may exchange DNA via a contact-dependent mechanism resembling bacterial conjugation.
Nedenskov-Sorensen, P., G. Bukholm, and K. Bovre, Natural competence for genetic transformation in Campylobacter pylori, J Infect Dis, 161, 365-366, 1990. |
As with several other bacterial species, including Neisseria spp. and Streptococcus pneumoniae, H. pylori is naturally competent for genetic transformation in vitro (125). This property allows for the uptake of exogenous DNA, which may subsequently replicate, in the case of plasmids, or incorporate into the chromosome by homologous recombination. In addition to genetic exchange via transformation, H. pylori strains may exchange DNA via a contact-dependent mechanism resembling bacterial conjugation (89).
89. Kuipers, E. J., D. A. Israel, J. G. Kusters, and M. J. Blaser. 1998. Evidence for a conjugation-like mechanism of DNA transfer in Helicobacter pylori. J. Bacteriol. 180:2901-2905. 125. Nedenskov-Sorensen, P., G. Bukholm, and K. Bovre. 1990. Natural competence for genetic transformation in Campylobacter pylori. J. Infect. Dis. 161:365-366. |
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