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Typus
KomplettPlagiat
Bearbeiter
Graf Isolan
Gesichtet
Yes.png
Untersuchte Arbeit:
Seite: 5, Zeilen: 1-9
Quelle: Wanken 2003
Seite(n): 6-7, Zeilen: 6:19-22; 7:4ff.
[This layer of gastric mucus, about 0.2-0.6 mm thick, is secreted] by epithelial cells and plays an important protective role in the stomach, both as a lubricant and as part of the gastric mucosal barrier against acid and pepsin. H. pylori thrives in this mucus environment. The mucus layer forms a stable, continuous layer over the mucosa and provides an environment for the neutralization of luminal acid, maintaining a near neutral pH at the mucosal surface (Ferrero, 2005).

According to studies employing light and electron microscopy and examination of stained gastric biopsies, H. pylori can be found both in the gastric mucus and in close proximity to the mucosal epithelial cells where it is protected from the acidic environment of the stomach lumen (Hazell et al., 1986; Liu et al., 2006).


Ferrero, R. L., Innate immune recognition of the extracellular mucosal pathogen, Helicobacter pylori, Mol Immunol, 42, 879-885, 2005.

Hazell, S. L., A. Lee, L. Brady, and W. Hennessy, Campylobacter pyloridis and gastritis: association with intercellular spaces and adaptation to an environment of mucus as important factors in colonization of the gastric epithelium, J Infect Dis, 153, 658-663, 1986.

Liu, Y., E. Hidaka, Y. Kaneko, T. Akamatsu, and H. Ota, Ultrastructure of Helicobacter pylori in human gastric mucosa and H. pylori-infected human gastric mucosa using transmission electron microscopy and the high-pressure freezing-freeze substitution technique, J Gastroenterol, 41, 569-574, 2006.

[Page 6]

This layer of gastric mucus, about 0.2-0.6 mm thick, is secreted by epithelial cells and plays an important protective role in the stomach, both as a lubricant and as part of the gastric mucosal barrier against acid and pepsin (62).

H. pylori thrives in a mucus environment.

[Page 7]

The mucus layer forms a stable, continuous layer over the mucosa and provides an environment for the neutralization of lumenal acid, maintaining a near neutral pH at the mucosal surface (5).

According to studies employing light and electron microscopy and examination of stained gastric biopsies, H. pylori can be found both in the gastric mucus and in close proximity to the mucosal epithelial cells where it is protected from the acidic environment of the stomach lumen (17, 68).


5. Allen, A. 1984. The structure and function of gastrointestinal mucous, p. 3-11. In E. C. Boedeker (ed.), Attachment of organisms to the gut mucosa, vol. II. CRC Press, Boca Raton.

17. Boren, T., S. Normark, and P. Faulk. 1994. Helicobacter pylori: Molecular basis for host recognition and bacterial adherence. Trends in Microbiology 2:221-8.

62. Goggin, P., and T. Northfield. 1993. Mucosal defence, p. 40-. In T. C. Northfield, M. Mendall, and P. M. Goggin (ed.), Helicobacter pylori infection. Kluwer Academic Publishers, Boston.

68. Hazell, S. L., A. Lee, L. Brady, and W. Hennessy. 1986. Campylobacter pyloridis and gastritis: Association with intracellular spaces and adaptation to an environment of mucus as important factors in colonization of the gastric epithelium. The Journal of Infectious Diseases 153:658-663.

Anmerkungen

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Sichter
(Graf Isolan), Hindemith

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