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Typus
Verschleierung
Bearbeiter
SleepyHollow02
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Untersuchte Arbeit:
Seite: 2, Zeilen: 1-9
Quelle: Wikipedia Small interfering RNA 2007
Seite(n): 1 (Internetquelle), Zeilen: -
[Most notably, siRNAs are involved in the RNA interference (RNAi) pathway] where the siRNA interferes with the expression of a specific gene (Tuschl et al, 2001). In addition to their role in the RNAi pathway, siRNAs also act in RNAi-related pathways, as an antiviral mechanism or in shaping the chromatin structure of a genome. siRNAs can also be exogenously (artificially) introduced into cells by various transfection methods to bring about the specific knockdown of a gene of interest. Essentially any gene of which the sequence is known can thus be targeted based on sequence complementarity with tailored siRNA. This has made siRNA an important tool for gene function and drug target validation studies in the post-genomic era. Most notably, siRNA is involved in the RNA interference (RNAi) pathway where the siRNA interferes with the expression of a specific gene. In addition to their role in the RNAi pathway, siRNAs also act in RNAi-related pathways, e.g. as an antiviral mechanism or in shaping the chromatin structure of a genome; the complexity of these pathways is only now being elucidated.

[...]

[...] SiRNAs can also be exogenously (artificially) introduced into cells by various transfection methods to bring about the specific knockdown of a gene of interest. Essentially any gene of which the sequence is known can thus be targeted based on sequence complementarity with an appropriately tailored siRNA. This has made siRNAs an important tool for gene function and drug target validation studies in the post-genomic era.

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