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SleepyHollow02
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Untersuchte Arbeit:
Seite: 2, Zeilen: 17-29
Quelle: Wikipedia microRNA 2007
Seite(n): 1 (Internetquelle), Zeilen: -
In genetics, miRNAs are single-stranded RNA molecules of about 21-23 nucleotides in length, which regulate gene expression. miRNAs are encoded by genes that are transcribed from DNA but not translated into protein (non-coding RNA); instead they are processed from primary transcripts known as pri-miRNAs to short stem-loop structures called pre-miRNAs and finally to function miRNAs. Mature miRNA molecules are partially complementary to one or more messenger RNA (mRNA) molecules, and their main function is to down-regulate gene expression.

1.1.3.1 Formation and processing of miRNA

The genes encoding miRNAs are much longer than the processed mature miRNA molecule; miRNAs are first transcribed as primary transcripts or pri-miRNAs with a cap and poly-A tail and processed to short, 70-nucleotide stem-loop structures known as pre-miRNAs in the cell nucleus. This [processing is performed in animals by a protein complex known as the Microprocessor complex, consisting of the nuclease Drosha and the and the double-stranded RNA binding protein Pasha (Denli et al, 2004).]

In genetics, microRNAs (miRNA) are single-stranded RNA molecules of about 21-23 nucleotides in length regulating gene expression. miRNAs are encoded by genes that are transcribed from DNA but not translated into protein (non-coding RNA); instead they are processed from primary transcripts known as pri-miRNA to short stem-loop structures called pre-miRNA and finally to functional miRNA. Mature miRNA molecules are partially complementary to one or more messenger RNA (mRNA) molecules, and their main function is to downregulate gene expression. [...]

[...]

The genes encoding miRNAs are much longer than the processed mature miRNA molecule; miRNAs are first transcribed as primary transcripts or pri-miRNA with a cap and poly-A tail and processed to short, 70-nucleotide stem-loop structures known as pre-miRNA in the cell nucleus. This processing is performed in animals by a protein complex known as the Microprocessor complex, consisting of the nuclease Drosha and the double-stranded RNA binding protein Pasha.[3]


3. Denli AM, Tops BB, Plasterk RH, Ketting RF, Hannon GJ. (2004). Nature 432(7014):231-5.

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