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Untersuchte Arbeit: Seite: 7, Zeilen: 22-28 |
Quelle: Geley and Mueller 2004 Seite(n): 985, Zeilen: r.col: 12ff |
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A major breakthrough in the elucidation of the underlying mechanism was the biochemical analysis of RNAi using Drosophila embryo or cell extracts (Tuschl et al., 1999; Hammond et al., 2000; Zamore et al., 2000), which led to the identification of the dsRNA processing enzyme Dicer (Bernstein et al., 2001a) as well as the RNA induced silencing complex, RISC (Hammond et al., 2000), which executes RNAi by using the small dsRNA species generated by Dicer as guidance molecules to target the homologous, endogenous mRNA for [degradation (Elbashir et al., 2001b,c; Zamore et al., 2000).] | A major breakthrough in the elucidation of the underlying mechanism was the biochemical analysis of RNAi using Drosophila embryo or cell extracts (Hammond et al., 2000; Tuschl et al., 1999; Zamore et al., 2000), which led to the identification of the dsRNA processing enzyme Dicer (Bernstein et al., 2001a) as well as the RNA induced silencing complex, RISC (Hammond et al., 2000), which executes RNAi by using the small dsRNA species generated by Dicer as guidance molecules to target the homologous, endogenous mRNA for degradation (Elbashir et al., 2001b,c; Zamore et al., 2000). |
Ein Verweis auf die Quelle fehlt. |
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