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Typus
Verschleierung
Bearbeiter
SleepyHollow02
Gesichtet
Yes
Untersuchte Arbeit:
Seite: 8, Zeilen: 22-28
Quelle: Hammond 2005
Seite(n): 5822, 5823, Zeilen: 5822: r.col. 36 ff.; 5823: l.col.: 26 ff.
The goal of the initiation step of RNAi is the generation of siRNAs from long dsRNAs or mature miRNAs from their primary transcripts. This is achieved by the action of two families of RNase III-dependent genes, Dicer and Drosha. RNase III enzymes fall into three classes (Nicholson, 2003). Class I enzymes, found in bacteria and yeast, contain a single RNase III domain joined to a dsRBD (dsRNA binding domain proteins). Class II and III enzymes contain two RNase III catalytic domains. Class III enzymes are further characterized [by a helicase domain and a PAZ (Piwi/Argonaute/Zwille) domain.] The goal of the initiator step of RNAi is the generation of siRNAs from long dsRNAs, or mature microRNAs from their primary transcripts. This is achieved by the action of two families of RNase III genes, Dicer and Drosha.

[Seite 5823]

RNaseIII enzymes fall into three classes (see Fig. 1, [11] for a review). Class I enzymes, found in bacteria and yeast, contain a single RNaseIII domain joined to a dsRBD. Class II and III enzymes contain two RNaseIII catalytic domains. Class III enzymes are further characterized by a helicase domain and a PAZ (Piwi/Argonaute/Zwille) domain.


[11] Nicholson, A.W. (2003) The ribonuclease III superfamily: forms and functions in RNA maturation, decay, and gene silencing (Hannon, G.J., Ed.), RNAi: A Guide to Gene Silencing, vol. 8, pp. 149–174, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.

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Sichter
(SleepyHollow02), Hindemith